Contactar Guilhermina Isabel dos Santos Duarte

Isabel Duarte

Categoria:

Investigador doutorado

Subsistema:

Investigação

Unidade de ID:

Centro de Investigação em Biomedicina

Regime:

Exclusividade

Vínculo:

CT em Funções Públicas a termo resolutivo certo

Ligações:

BioSketch

About my Science | I am a full time scientific researcher, and curiosity is my main driver. I am passionate about Open Science and I am always keen on establishing new collaborations.

Synopsis | I did my PhD in the Comics group at the CMBI in Nijmegen, The Netherlands. I have a Masters degree in Oncology by ICBAS - Universidade do Porto (Portugal), and a Bachelor degree in Applied Biology by Universidade do Minho Braga (Portugal). I have published 18 articles in international peer reviewed journals.

Past works | I use Bioinformatics/Computational Biology as a way of answering biologically relevant questions. I have used OMICs datasets to study the genetic regulation of early vertebrate embryo development, stem cell differentiation, and mitochondrial evolution.

Insterests | My research interests are focused on understanding how gene expression profiles translate into robust genetic modules that explain the phenotypic plasticity observed in healthy and diseased cells. Such genetic modules hold the promise to be used as markers for precision medicine (diagnostic/prognostic classifiers of cellular phenotypic potential), but most importantly, this knowledge will help me to better understand the underlying basis of cell biology.

Detalhes

Projetos

Participation in Projects

2019 – present

Bioinformatics researcher | CBMR - Universidade do Algarve (Faro, Portugal) | Functional Genomics of Cancer Lab
FCT Project | DEvoCancer: Decoding breast cancer evolution through mutant allele differential expression signatures | Team member

2016 – 2019

Bioinformatics researcher | CBMR - Universidade do Algarve - Faro, Portugal | Temporal Control of Cell Differentiation Lab
TIMING CELL DIFFERENTIATON: Gene Regulatory Network in Temporal Control of Mesoderm Specification (Project)

2014 – 2015

Bioinformatics researcher | CBMR - Universidade do Algarve - Faro, Portugal | Systems Biology Lab
SPLICE: Alternative splicing and its impact on molecular networks during stem cell differentiation (Project)

2012 - 2013

Bioinformatics expert analist for European ERASysBio+ project | Radboud University (The Netherlands) & University of Birmingham (United Kingdom) & University of Jena (Germany) | Cell and Applied Biology Lab
LINCONET: Modelling the gene regulatory network underlying lineage commitment in human Mesenchymal Stem Cells (Project)

Publicações

Duarte I and Huynen MA. Contribution of Lateral Gene Transfer to the evolution of the eukaryotic fungus Piromyces sp. E2: Massive bacterial transfer of genes involved in carbohydrate metabolism. BioRxiv. 2019. (DOI: https://doi.org/10.1101/514042)
Pais-de-Azevedo T, Magno R, Duarte I and Palmeirim I. Recent advances in understanding vertebrate segmentation. F1000 Research. 2018. (PMID: 29416855)
Pinto JP, Machado RSR, Magno R, Oliveira DV, Machado S, Andrade RP, Bragança J, Duarte I and Futschik ME. StemMapper: a curated gene expression database for stem cell lineage analysis. Nucleic Acids Research. 2017. (PMID: 29045725)
Magno R, Duarte I, Andrade RP and Palmeirim I. rdml: A Mathematica package for parsing and importing Real-Time qPCR data. BMC Research Notes. 2017. (PMID: 28606167)
Macedo JA, Schrama D, Duarte I, Tavares E, Renaut J, Futschik ME, Rodrigues PM and Melo EP. Membrane-enriched Proteomic changes Associated with Prion protein expression during Neural Differentiation and in Neuroblastoma Cells. BMC Genomics. 2017. (PMID: 28431525)
Pinto E, Anselmo M, Calha M, Bottrill A, Duarte I, Andrew PW and Faleiro ML. The Intestinal Proteome of Diabetic and Control children are Enriched with Different Microbial and Host proteins. Microbiology (UK). 2017. (PMID: 28270263)
van Zoelen EJ, Duarte I, Hendriks JM and van der Woning SP. TGFB-Induced Switch from Adipogenic to Osteogenic Differentiation of Human Mesenchymal Stem Cells: Identification of drug targets for prevention of fat cell differentiation. Stem Cell Research & Therapy. 2016. (PMID: 27562730)
Pinto JP, Kalathur RK, Oliveira DV, Barata T, Machado RS, Machado S, Pacheco-Leyva I, Duarte I and Futschik ME. StemChecker: a web-based tool to discover and explore stemness signatures in gene sets. Nucleic Acids Research. 2015. (PMID: 26007653)
Huynen MA, Duarte I and Szklarczyk R. Loss, replacement and gain of proteins at the origin of the mitochondria. Biochimica et Biophysica Acta - Bioenergetics. 2013. (PMID: 22902511)
Willems P, Wanschers B, Esseling J, Szklarczyk R, Kudla U, Duarte I, Forkink M, Nooteboom M, Swarts H, Gloerich J, Nijtmans L, Koopman W and Huynen MA. BOLA1 is an aerobic protein that prevents mitochondrial morphology changes induced by glutathione depletion. Antioxidants & Redox Signaling. 2013. (PMID: 22746225)
Kensche PR, Duarte I and Huynen MA. A three-dimensional topology of complex I inferred from evolutionary correlation. BMC Structural Biology. 2012. (PMID: 22857522)
Duarte I, Naaburs SB, Magno R and Huynen MA. Evolution and diversification of the organellar release factor family. Molecular Biology and Evolution. 2012. (PMID: 22688947)
Huynen MA, Duarte I, Chrzanowska-Lightowlers ZM and Naaburs SB. Structure based hypothesis of a mitochondrial ribosome rescue mechanism. Biologyl Direct. 2012. (PMID: 22569235)
de Graaf RM, Ricard G, van Alen TA, Duarte I, Dutilh BE, Burgtorf C, Kuiper JW, van der Staay GW, Tielens AG, Huynen MA, Hackstein JH. The organellar genome and metabolic potential of the hydrogen-producing mitochondrion of Nyctotherus ovalis. Molecular Biology and Evolution. 2011. (PMID: 21378103)
Duarte I, de Graaf RM, van Alen TA, Kuiper JW, Schotanus K, Rosenberg J, Huynen MA, Hackstein JH. The hydrogenosomes of Psalteriomonas lanterna. BMC Evolutionary Biology. 2009. (PMID: 20003182)
Ricard G, de Graaf RM, Dutilh BE, Duarte I, van Alen TA, van Hoek AH, Boxma B, van der Staay GW, Moon-van der Staay SY, Chang WJ, Landweber LF, Hackstein JH, Huynen MA. Macronuclear genome structure of the ciliate Nyctotherus ovalis: single-gene chromosomes and tiny introns. BMC Genomics. 2008. (PMID: 19061489)
Santos AM, Sousa H, Pinto D, Portela C, Pereira D, Catarino R, Duarte I, Lopes C, Medeiros R. Linking TP53 codon 72 and P21 nt590 genotypes to the development of cervical and ovarian cancer. European Journal of Cancer. 2006. (PMID: 16542834)
Duarte I, Santos AM, Sousa H, Catarino R, Pinto D, Matos A, Pereira D, Moutinho J, Canedo P, Machado JC, Medeiros R. G-308A TNF-alpha Polymorphism is Associated with an Increased Risk of Invasive Cervical Cancer. Biochemical and Biophysical Research Communications. 2005. (PMID: 16009345)

Contacto

Contactar Guilhermina Isabel dos Santos Duarte

Isabel Duarte

Detalhes

Participation in Projects​​​​​​​

Participation in Projects